An official at Maersk's Hong Kong subsidiary believes the current 100 or so boxes that are carried from the Portuguese colony to the SAR could soar with the link's opening.
"It will provide an easier route into Hong Kong so goods can be carried from Macau for shipment out to the rest of the world," Maersk Hong Kong deputy managing director, Steen Lund, said.
Chinese authorities are mulling the idea of building a 50-kilometre long coastal sea bridge from Zhuhai, Macau's closest mainland city, to Hong Kong's Tsuen Mun.
Few concrete plans have been put in motion, but economists say the multi-billion dollar project would make financial sense.
"One of the problems of getting freight from Macau to Hong Kong is that the trucking is so difficult," Lund said.
Terrain and trucking distances from the Zhuhai special economic zone forced companies to locate their production plants nearer Hong Kong or its mainland sister port Shenzhen, Lund said.
Maersk Hong Kong managing director, Ulrich Brandt, earlier pointed to the double borders, around Hong Kong and around the special economic zones, as further hindrances to manufactuirers setting up shop near Macau.
They added administrative, operational costs and time costs, Brandt added.
Although Macau is producing small cargo volumes for trans-shipment from the SAR, Lund says he wouldn't be surprised if such levels rocketed come the opening of the link.
"I am sure there are lots of companies who like to locate nearer to Macau, and lots of manufacturers who are based in Macau but would rather not have plants in Shenzhen. It makes sense."
The road bridge, which is expected to link the under-construction Macau-Zhuhai highway with Hong Kong's Kwai Chung port-Chek Lap Kok airport expressway, is not expected to be finished before second half of the next decade.
"So there is still a lot of time to go, and we don't really think things are going to change an awful lot for Macau before then," Lund said. "The market isn't that big and it doesn't yet, really, have the production capacity to generate a lot of freight."
Maersk has a small office in Macau to handle bookings from the colony and the surrounding economic zone, and to feed freight on to the line's major calls at Hong Kong.